Comparison of ZnO doped different phases TiO2 nanoparticles in terms of toxicity using zebrafish (Danio rerio)

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dc.contributor.authorSezer, Selda
dc.contributor.authorYucel, Aysegul
dc.contributor.authorTurhan, Duygu Ozhan
dc.contributor.authorEmre, Fatma Bilge
dc.contributor.authorSarikaya, Musa
dc.date.accessioned2026-06-19T06:40:02Z
dc.date.available2026-06-19T06:40:02Z
dc.date.issued2023
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractTitanium dioxide is used in many commercial and industrial areas such as paint, paper, cosmetics, textiles, and surface coating. The reasons for its use in such a wide area are its anti-corrosion and high stability. Although TiO2 is considered to be a low-toxicity material, research has been further expanded following the recognition of the possible carcinogenic effects of TiO2 in humans by the International Agency for Research on Cancer (IARC). The aim of this study is to compare the toxicity of TiO2 used in many fields in different phases. In the study anatase TiO2 synthesized by hydrothermal method and dual phase TiO2 (anatase and rutile phase) structures obtained by thermal conditioning were used and compared with commercially available TiO2. ZnO which has similar uses like TiO2 was also used and compared with 1% doped TiO2 in different phases in terms of toxicity. Zebrafish (Danio rerio, D. rerio), a freshwater fish, which is widely used in toxicity assessments was preferred in this study due to its small size, fast reproduction rate, low cost, physiological and molecular similarity with humans, and genetic predisposition. Experimental investigations showed that the highest death occurred in the low concen-trations of (10 ppm) ZnO doped rutile phase. 39% of the embryos died in the ZnO nanoparticle solutions pre-pared at low concentrations. The highest mortality at medium (100 ppm) and high (1000 ppm) concentrations were observed in the ZnO-doped rutile phase after 96 h. Similarly, the highest malformation was detected in the ZnO-doped rutile phase during the same period.
dc.description.sponsorshipInonu University Scientific Research Projects Coordination Unit [FDK- 2020 - 2114]; Inonu University the Scientific and Technological Research Center
dc.description.sponsorshipS.S. and A.Y contributed equally to this work. All authors would like to thank for their financial support to the Inonu University Scientific Research Projects Coordination Unit (Project Number: FDK- 2020 - 2114) . Additionally, they would like to thank Inonu University the Scientific and Technological Research Center for providing device sup- port for the material characterization.
dc.identifier.doi10.1016/j.chemosphere.2023.138342
dc.identifier.issn0045-6535
dc.identifier.issn1879-1298
dc.identifier.orcid0000-0001-7069-7518
dc.identifier.orcid0000-0002-3136-1250
dc.identifier.pmid36933837
dc.identifier.scopus2-s2.0-85150438639
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.1016/j.chemosphere.2023.138342
dc.identifier.urihttps://hdl.handle.net/20.500.12899/5922
dc.identifier.volume325
dc.identifier.wosWOS:000957537200001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherPergamon-Elsevier Science Ltd
dc.relation.ispartofChemosphere
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260612
dc.subjectNanoparticle
dc.subjectToxicity
dc.subjectZebrafish
dc.subjectAnatase Phase
dc.subjectRutile Phase
dc.subjectDual Phase
dc.titleComparison of ZnO doped different phases TiO2 nanoparticles in terms of toxicity using zebrafish (Danio rerio)
dc.typeArticle

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