Usefulness of Preprocedural Serum Uric Acid Level to Predict Restenosis of Bare Metal Stents

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dc.authoridOzcan, Firat/0000-0002-7954-7839|Canpolat, Ugur/0000-0002-4250-1706;
dc.contributor.authorTurak, Osman
dc.contributor.authorCanpolat, Ugur
dc.contributor.authorOzcan, Firat
dc.contributor.authorMendi, Mehmet Ali
dc.contributor.authorOksuz, Fatih
dc.contributor.authorIsleyen, Ahmet
dc.contributor.authorGurel, Ozgul Malcok
dc.date.accessioned2025-10-24T18:08:58Z
dc.date.available2025-10-24T18:08:58Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractSerum uric acid (SUA) level is known as a significant predictor for cardiovascular diseases, partly through increased inflammatory response and smooth muscle cell proliferation. Inflammation and smooth muscle cells play a crucial role in the pathogenesis of in-stent restenosis (ISR). However, the relation between SUA and ISR has not been studied. The aim of the present study was to investigate the predictive value of preprocedural SUA on the development of ISR in patients who undergo coronary bare-metal stent implantation. Clinical, biochemical, and angiographic data from 708 consecutive patients (mean age 60.3 +/- 9.3 years, 71% men) who had undergone bare-metal stent implantation and additional control coronary angiography for stable or unstable angina pectoris were analyzed. Patients were divided into tertiles on the basis of preprocedural SUA levels. Stent restenosis was observed in 54 patients (23%) in the lowest tertile, in 79 (34%) in the middle tertile, and in 109 (46%) in the highest tertile (p < 0.001). Using multiple logistic regression analysis, diabetes mellitus, smoking, high-density lipoprotein cholesterol, stent length, C-reactive protein level, and preprocedural SUA level emerged as independent predictors of ISR. On receiver-operating characteristics curve analysis, SUA level >5.5 mg/dl had 75% sensitivity and 71% specificity (area under the curve 0.784, p < 0.001) in predicting ISR. In conclusion, higher preprocedural SUA is a powerful and independent predictor of bare-metal stent restenosis in patients with stable and unstable angina pectoris. (C) 2014 Elsevier Inc. All rights reserved.
dc.identifier.doi10.1016/j.amjcard.2013.09.004
dc.identifier.endpage202
dc.identifier.issn0002-9149
dc.identifier.issn1879-1913
dc.identifier.issue2
dc.identifier.pmid24157191
dc.identifier.scopus2-s2.0-84891629964
dc.identifier.scopusqualityQ2
dc.identifier.startpage197
dc.identifier.urihttps://doi.org/10.1016/j.amjcard.2013.09.004
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3376
dc.identifier.volume113
dc.identifier.wosWOS:000330253900001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherExcerpta Medica Inc-Elsevier Science Inc
dc.relation.ispartofAmerican Journal Of Cardiology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectC-Reactive Protein; Percutaneous Coronary Intervention; Inflammatory Biomarkers; Cell-Proliferation; Disease; Atherosclerosis; Implantation; Angioplasty; Hyperplasia; Antioxidant
dc.titleUsefulness of Preprocedural Serum Uric Acid Level to Predict Restenosis of Bare Metal Stents
dc.typeArticle

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