Effects of cepae extract, allantoin, and heparin mixture on developing and already formed epidural fibrosis in a rat laminectomy model

Basit Öğe Kaydı
dc.authoridYIGIT, FUNDA/0000-0001-5370-961X|Ozay, Rafet/0000-0001-5982-4897|YAVUZ, OSMAN/0000-0003-4141-2944|Cetinalp, Nuri Eralp/0000-0002-1008-9171;
dc.contributor.authorOzay, Rafet
dc.contributor.authorYavuz, Osman Yuksel
dc.contributor.authorAktas, Abit
dc.contributor.authorYigit, Funda
dc.contributor.authorCetinalp, Nuri Eralp
dc.contributor.authorOzdemir, Haci Mustafa
dc.contributor.authorSekerci, Zeki
dc.date.accessioned2025-10-24T18:09:56Z
dc.date.available2025-10-24T18:09:56Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground/aim: The study was designed to investigate whether local administration of a mixture composed of cepae extract, allantoin, and heparin (CAH) decreased already formed epidural fibrosis (EF) at the laminectomy site. Materials and methods: Twenty- four adult male Sprague Dawley rats were equally divided into four groups. Laminectomy was performed at the L5 level in all rats. The group 2 and group 4 rats were treated with local drug administration. While the group 1 and 2 rats were sacrificed after 6 weeks, the remaining rats were reoperated and CAH mixture was applied in group 4. The vertebral columns of all rats were removed en bloc. Fibroblast numbers, EF, and arachnoidal involvement (AI) were evaluated. Results: The results of the treatment groups were separately compared with the control groups. The numbers of fibroblasts in the treatment groups were significantly lower than those in the control groups (P < 0.001). The grade of EF in group 2 was significantly less than that in group 1 (P < 0.05). There was no statistically significant difference regarding EF and AI grade between group 3 and group 4, and local application of the drug on EF and AI yielded better results than in the control groups. Conclusion: The mixture composed of CAH might be a successful candidate for preventing EF in clinical practice.
dc.identifier.doi10.3906/sag-1504-16
dc.identifier.endpage1239
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue4
dc.identifier.pmid27513430
dc.identifier.scopus2-s2.0-84975841162
dc.identifier.scopusqualityQ1
dc.identifier.startpage1233
dc.identifier.trdizinid249853
dc.identifier.urihttps://doi.org/10.3906/sag-1504-16
dc.identifier.urihttps://search.trdizin.gov.tr/tr/yayin/detay/249853
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3881
dc.identifier.volume46
dc.identifier.wosWOS:000378646700043
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakTR-Dizin
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectLaminectomy; rat; fibrosis; cepae; allantoin; heparin
dc.titleEffects of cepae extract, allantoin, and heparin mixture on developing and already formed epidural fibrosis in a rat laminectomy model
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
TR-Dizin İndeksli Yayınlar Koleksiyonu