The effects of disease severity and comorbidity on oxidative stress biomarkers in obstructive sleep apnea

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dc.contributor.authorKiran, Tugba Raika
dc.contributor.authorOtlu, Onder
dc.contributor.authorErdem, Mehmet
dc.contributor.authorGeckil, Aysegul Altintop
dc.contributor.authorBerber, Nurcan Kirici
dc.contributor.authorIn, Erdal
dc.date.accessioned2026-06-19T06:41:04Z
dc.date.available2026-06-19T06:41:04Z
dc.date.issued2024
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractPurposeIschemia-modified albumin (IMA), total oxidant status (TOS), and total antioxidant status (TAS) are biomarkers used to evaluate oxidative stress status in various diseases including obstructive sleep apnea (OSA). In this study, we investigated the effects of disease severity and comorbidity on IMA, TOS and TAS levels in OSA.MethodsPatients with severe OSA (no-comorbidity, one comorbidity, and multiple comorbidities) and mild-moderate OSA (no-comorbidity, one and multiple comorbidities), and healthy controls were included in the study. Polysomnography was applied to all cases and blood samples were taken from each participant at the same time of day. ELISA was used to measure IMA levels in serum samples and colorimetric commercial kits were used to perform TOS and TAS analyses. In addition, routine biochemical analyses were performed on all serum samples.ResultsA total of 74 patients and 14 healthy controls were enrolled. There was no statistically significant difference between the disease groups according to gender, smoking status, age, body mass index (BMI), HDL, T3, T4, TSH, and B12 (p > 0.05). As the severity of OSA and comorbidities increased, IMA, TOS, apnea-hypopnea index (AHI), desaturation index (T90), cholesterol, LDL, triglyceride, AST, and CRP values increased significantly (p < 0.05). On the other hand, TAS, minimum desaturation, and mean desaturation values decreased significantly (p < 0.05).ConclusionsWe concluded that IMA, TOS, and TAS levels may indicate OSA-related oxidative stress, but as the severity of OSA increases and with the presence of comorbidity, IMA and TOS levels may increase and TAS levels decrease. These findings suggest that disease severity and presence/absence of comorbidity should be considered in studies on OSA.
dc.identifier.doi10.1007/s11325-023-02870-9
dc.identifier.endpage163
dc.identifier.issn1520-9512
dc.identifier.issn1522-1709
dc.identifier.issue1
dc.identifier.orcid0000-0002-9100-2479
dc.identifier.orcid0000-0001-5958-7609
dc.identifier.orcid0000-0002-3724-0249
dc.identifier.orcid0000-0002-8807-5853
dc.identifier.pmid37430029
dc.identifier.scopus2-s2.0-85164466928
dc.identifier.scopusqualityQ1
dc.identifier.startpage151
dc.identifier.urihttps://doi.org/10.1007/s11325-023-02870-9
dc.identifier.urihttps://hdl.handle.net/20.500.12899/6052
dc.identifier.volume28
dc.identifier.wosWOS:001025581700001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer Heidelberg
dc.relation.ispartofSleep and Breathing
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260612
dc.subjectIschemia-Modified Albumin
dc.subjectObstructive Sleep Apnea Syndrome
dc.subjectOxidative Stress
dc.subjectPolysomnography
dc.subjectTotal Oxidant Status
dc.subjectTotal Antioxidant Status
dc.titleThe effects of disease severity and comorbidity on oxidative stress biomarkers in obstructive sleep apnea
dc.typeArticle

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