Evaluation of hepatosteatosis and gallstone disease in patients with chronic kidney disease

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dc.contributor.authorKarahan, Dogu
dc.contributor.authorSahin, Idris
dc.date.accessioned2026-06-19T06:39:21Z
dc.date.available2026-06-19T06:39:21Z
dc.date.issued2024
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractIntroduction: The prevalence rates of hepatosteatosis and gallstones are increasing owing to the multifactorial causes of chronic kidney disease, and the prevalence may change with the availability of different forms of renal replacement therapy. We aimed to determine the incidence or prevalence rates of hepatosteatosis, cholelithiasis, and acute cholecystitis in patients with chronic kidney disease and compare them between renal replacement therapy modalities. Methods: A total of 270 patients (90 with chronic kidney disease stages III-V, 90 undergoing peritoneal dialysis, and 90 undergoing hemodialysis) were included and categorized into the pre-dialysis, hemodialysis, and peritoneal dialysis groups. The patients were questioned about previous gallbladder surgeries and chronic diseases. The results of abdominal ultrasonography, tomography, and magnetic resonance imaging were retrospectively evaluated with respect to the findings on the hepatobiliary system. Hepatosteatosis and cholelithiasis were diagnosed by expert radiologists on the basis of abdominal ultrasonography, tomography, and magnetic resonance imaging findings. The prevalence rates of hepatosteatosis, cholelithiasis, and other liver findings were compared between the groups. Findings: Hepatosteatosis and cholelithiasis were detected in 16.7% and 21.5% of the 270 cases, respectively. Hepatosteatosis was present in 17.8%, 25.6%, and 6.7% of patients in the pre-dialysis, hemodialysis, and peritoneal dialysis groups, respectively. The prevalence of hepatosteatosis was significantly higher in patients undergoing hemodialysis than in patients undergoing peritoneal dialysis (p = 0.002). However, no statistically significant difference was found between the peritoneal dialysis and pre-dialysis groups or between the hemodialysis and pre-dialysis groups (p >0.05). The prevalence rates of cholelithiasis were 15.6%, 28.9%, and 20.0%, in the pre-dialysis, hemodialysis, and peritoneal dialysis groups, respectively, and there were no statistically significant differences among the groups. The incidence of acute cholecystitis was significantly higher in the hemodialysis group than in the pre-dialysis group (p = 0.006). Discussion: Our study showed that the hepatobiliary system is frequently affected in chronic kidney disease and that the findings may differ depending on the renal replacement therapy modality.
dc.identifier.doi10.1111/hdi.13151
dc.identifier.endpage350
dc.identifier.issn1492-7535
dc.identifier.issn1542-4758
dc.identifier.issue3
dc.identifier.orcid0000-0002-5387-2000
dc.identifier.orcid0000-0002-8683-3737
dc.identifier.pmid38558287
dc.identifier.scopus2-s2.0-85189635105
dc.identifier.scopusqualityQ3
dc.identifier.startpage343
dc.identifier.urihttps://doi.org/10.1111/hdi.13151
dc.identifier.urihttps://hdl.handle.net/20.500.12899/5564
dc.identifier.volume28
dc.identifier.wosWOS:001194177300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofHemodialysis International
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_WOS_20260612
dc.subjectChronic Kidney Disease
dc.subjectGallstone
dc.subjectHemodialysis
dc.subjectHepatosteatosis
dc.subjectPeritoneal Dialysis
dc.titleEvaluation of hepatosteatosis and gallstone disease in patients with chronic kidney disease
dc.typeArticle

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