Effects of COVID-19 Lockdown on Time in Therapeutic Range (TTR) for Warfarin Users

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dc.contributor.authorAktaş, İbrahim
dc.contributor.authorSarıoğlu, Güney
dc.contributor.authorYaşar, Erdoğan
dc.date.accessioned2026-06-19T06:24:05Z
dc.date.available2026-06-19T06:24:05Z
dc.date.issued2025
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstract<p><strong>Objectives: </strong>This study investigated the impact of COVID-19 lockdown measures on Time in Therapeutic Range (TTR) for patients receiving warfarin therapy.</p><p><strong>Methods: </strong>A retrospective cohort study was conducted at a tertiary care hospital in Malatya. Patients receiving warfarin for at least one year before and after March 11th, 2020 (the start of pandemic) were included (n=112). Demographic data, comorbidities, medications, and International Normalized Ratio (INR) results were collected. TTR was calculated using the Rosendaal method.</p><p><strong>Results: </strong>The mean TTR before the pandemic was 56.91%, significantly higher than the 40.23% observed during the pandemic (P&lt;0.001). INR measurement intervals also increased significantly during the pandemic (34.2 days pre-pandemic vs. 50.9 days during the pandemic, P&lt;0.001). This effect was most pronounced in patients over 65 years old (P&lt;0.001).</p><p><strong>Conclusions: </strong>COVID-19 lockdown measures significantly decreased TTR and extended INR monitoring intervals for warfarin users. These findings were particularly concerning in the elderly population. Strategies to ensure optimal warfarin monitoring during pandemics or disasters are crucial to prevent complications.</p>
dc.identifier.dergipark1802705
dc.identifier.doi10.18621/eurj.1802705
dc.identifier.endpage691
dc.identifier.issn2149-3189
dc.identifier.issueAdvanced Online Publication
dc.identifier.orcid0000-0002-2982-8384
dc.identifier.orcid0000-0002-1049-1873
dc.identifier.orcid0000-0001-5882-3534
dc.identifier.startpage685
dc.identifier.urihttps://doi.org/10.18621/eurj.1802705
dc.identifier.urihttps://hdl.handle.net/20.500.12899/4316
dc.language.isoen
dc.publisherPrusa Medical Publishing
dc.relation.ispartofThe European Research Journal
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_DergiPark_20260612
dc.subjectCOVID Lockdown
dc.subjectWarfarin
dc.subjectTime in Therapeutic Range
dc.subjectINR Monitoring
dc.titleEffects of COVID-19 Lockdown on Time in Therapeutic Range (TTR) for Warfarin Users
dc.typeArticle

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