Cut-off value for interleukin-34 as an additional potential inflammatory biomarker for estimation of slow coronary flow risk

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dc.contributor.authorKarasu, Mehdi
dc.contributor.authorBolayir, Hasan Ata
dc.date.accessioned2026-06-19T06:38:18Z
dc.date.available2026-06-19T06:38:18Z
dc.date.issued2024
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground Inflammatory markers may provide insights into the underlying mechanisms of slow coronary flow (SCF), including subclinical atherosclerosis and endothelial dysfunction. Interleukin-34 (IL-34), known for its role in immuno-inflammatory diseases, might hold significance in SCF. We aimed to explore the potential association between IL-34 and SCF in patients undergoing diagnostic elective coronary angiography.Methods This observational, cross-sectional study enrolled 256 participants: 124 with SCF and 132 with normal coronary flow (NCF). All participants had undergone outpatient coronary angiography for suspected coronary artery disease. SCF assessment employed the TIMI frame count (TFC) for quantifying coronary flow rate.Results SCF patients exhibited significantly elevated TFC in all three major coronary arteries compared to controls (p < 0.05). IL-34 displayed a noteworthy positive correlation with average TFC [for all participants: r = 0.514, p < 0.001; for SCF patients: r = 0.526, p < 0.001; for normal controls: r = -0.288, p > 0.05]. Similarly, high-sensitivity C-reactive protein (hsCRP) showed a significant and positive relationship with average TFC [for all participants: r = 0.504, p < 0.001; for SCF patients: r = 0.558, p < 0.001; for normal controls: r = -0.148, p > 0.05]. SCF patients presented coronary arteries of larger size compared to controls.Conclusion Mean coronary diameter and IL-34 emerged as independent predictors of SCF. Additionally, hsCRP, mean coronary diameter, and IL-34 exhibited a positive correlation with mean TFC values. IL-34 appears to be a more effective indicator than hsCRP in SCF patients.
dc.identifier.doi10.1186/s12872-023-03677-y
dc.identifier.issn1471-2261
dc.identifier.issue1
dc.identifier.orcid0000-0002-3557-1175
dc.identifier.orcid0000-0003-1713-3451
dc.identifier.pmid38166811
dc.identifier.scopus2-s2.0-85181240740
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.1186/s12872-023-03677-y
dc.identifier.urihttps://hdl.handle.net/20.500.12899/5496
dc.identifier.volume24
dc.identifier.wosWOS:001135329800007
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBmc
dc.relation.ispartofBmc Cardiovascular Disorders
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260612
dc.subjectIl-34
dc.subjectHscrp
dc.subjectSlow Coronary Flow (Scf)
dc.titleCut-off value for interleukin-34 as an additional potential inflammatory biomarker for estimation of slow coronary flow risk
dc.typeArticle

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