Role of ADAMTS1 and ADAMTS5 in male infertility

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dc.authoridYukselten, Yunus/0000-0003-4944-0819|Aydos, Kaan/0000-0001-7691-5459|SUNGUROGLU, ASUMAN/0000-0001-7693-0958|Aydos, Oya Sena/0000-0001-6978-3566;
dc.contributor.authorAydos, S. E.
dc.contributor.authorYukselten, Y.
dc.contributor.authorSunguroglu, A.
dc.contributor.authorDemircan, K.
dc.contributor.authorAydos, K.
dc.date.accessioned2025-10-24T18:09:22Z
dc.date.available2025-10-24T18:09:22Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractThe aim of this study was to investigate the relationship of infertility with metalloproteinases ADAMTS1 and ADAMTS5, which are known to be responsible for the degradation of extracellular matrix (ECM) proteins associated with many diseases. ECM is the noncellular component that provides structural and biochemical support to the surrounding cells required for tissue morphogenesis, differentiation and homoeostasis. Sixty infertile individuals and 10 healthy semen donors were included in this study. The infertile individuals were classified as normozoospermia (NS; n = 20), oligozoospermia (OS; n = 20), azoospermia (AS; n = 20) groups. ADAMTS1 and ADAMTS5 protein levels in semen were analysed by Western blot. ADAMTS1 protein level was 3.0-, 3.3- and 1.6-fold lower in the OS, AS and NS groups, respectively, than in the control group (P < 0.001). ADAMTS5 protein level was 3.2-, 2.7- and 1.4-fold lower in the OS, AS and NS groups, respectively, than in the control group (P < 0.001). Sperm count and sperm motility showed a negative correlation with the levels of ADAMTS1 and ADAMTS5 protein expression: r = -0.477, r = -0.470; and r = -0.332, r = -0.275 respectively (P < 0.001). In conclusion, ADAMTS1 and ADAMTS5 protein expressions in semen are significantly related with sperm production. It is very important to understand molecular function and organisation of ADAMTSs which will be significant in enlightening the process of spermatogenesis in male infertility.
dc.identifier.doi10.1111/and.12547
dc.identifier.endpage1119
dc.identifier.issn0303-4569
dc.identifier.issn1439-0272
dc.identifier.issue10
dc.identifier.pmid26888488
dc.identifier.scopus2-s2.0-84997119457
dc.identifier.scopusqualityQ1
dc.identifier.startpage1113
dc.identifier.urihttps://doi.org/10.1111/and.12547
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3603
dc.identifier.volume48
dc.identifier.wosWOS:000389219000007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWiley
dc.relation.ispartofAndrologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectExtracellular matrix; male infertility; metalloproteinases
dc.titleRole of ADAMTS1 and ADAMTS5 in male infertility
dc.typeArticle

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