Benefits of the Neutrophil-to-Lymphocyte Ratio for the Prediction of Gestational Diabetes Mellitus in Pregnant Women

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dc.authoridBilgic, Mukadder Ayse/0000-0003-0621-8273;
dc.contributor.authorYilmaz, H.
dc.contributor.authorCelik, H. T.
dc.contributor.authorNamuslu, M.
dc.contributor.authorInan, O.
dc.contributor.authorOnaran, Y.
dc.contributor.authorKarakurt, F.
dc.contributor.authorAyyildiz, A.
dc.date.accessioned2025-10-24T18:09:12Z
dc.date.available2025-10-24T18:09:12Z
dc.date.issued2014
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractAims: There is growing consensus in the literature that inflammation plays a central role in the pathophysiology of obesity, Type 2 Diabetes Mellitus (T2DM), Gestational Diabetes Mellitus (GDM) and cardiovascular complications. Measuring the neutrophil-to-lymphocyte ratio (NLR) provides a simple inexpensive method for the assessment of inflammatory status. We investigated the predictive value of pre-procedural (before the oral glucose tolerance test (OGTT)) NLR on the development of GDM in pregnancy. Methods: 42 women with GDM and 68 women without GDM were included in the study. Complete Blood Count and biochemical tests were followed by a diagnostic 4-point 100-g-OGTT within 2 weeks. GDM was diagnosed by the Carpenter and Coustan criteria. The NLR was calculated from the data. Results: The mean NLR level was significantly higher in GDM women (3.00 +/- 0.83 vs. 2.26 +/- 0.43 p < 0.001, respectively). In ROC analysis, NLR > 2.93 had 76.2 % sensitivity and 94.1 % specificity in predicting GDM. Logistic regression analysis showed that elevated NLR (OR: 5.512, 95 % CI: 1.352-22.475, p = 0.017) was an independent variable for predicting GDM in pregnancy. Conclusions: An elevated NLR level is a powerful and independent predictor of GDM. The results of this study suggested that inflammation plays a central role in the pathogenesis of GDM.
dc.identifier.doi10.1055/s-0033-1361087
dc.identifier.endpage43
dc.identifier.issn0947-7349
dc.identifier.issn1439-3646
dc.identifier.issue1
dc.identifier.pmid24464596
dc.identifier.scopus2-s2.0-84893154594
dc.identifier.scopusqualityQ2
dc.identifier.startpage39
dc.identifier.urihttps://doi.org/10.1055/s-0033-1361087
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3520
dc.identifier.volume122
dc.identifier.wosWOS:000334491000008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherJohann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbh
dc.relation.ispartofExperimental And Clinical Endocrinology & Diabetes
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectGamma-Glutamyl-Transferase; Serum Uric-Acid; Insulin-Resistance; Inflammation; Risk; Atherosclerosis; Cohort
dc.titleBenefits of the Neutrophil-to-Lymphocyte Ratio for the Prediction of Gestational Diabetes Mellitus in Pregnant Women
dc.typeArticle

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