Investigation of Electrocardiographic Changes Caused by Antepileptic Drugs in Epilepsy Patients

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dc.contributor.authorDemir, B.
dc.contributor.authorŞahin, L.
dc.date.accessioned2026-06-19T06:32:06Z
dc.date.available2026-06-19T06:32:06Z
dc.date.issued2024
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground: One of the metabolic effects of antiepileptic drugs (AEDs) is cardiac changes. Aim: In our study, to investigate the cardiac effects of AED use; We looked at electrocardiography (ECG) samples performed on patients. By looking at ECG variables, we tried to determine their relationship with epileptic seizure types and antiepileptic drugs. Methods: This prospective study was completed with a total of 50 epilepsy patients whose ECGs were recorded after exclusion criteria. The number of years the patients had epilepsy, the frequency of seizures, the duration of seizures, and the AEDs they used were recorded. Standard 12-lead ECG was applied to the patients, and QT intervals, Tp-e interval, Tp-e/QT ratio, and Tp-e/QTd ratio were measured. Results: Patients most commonly use levatiracetam, valproic acid (VPA), carbamazepine, and lamotrigine, respectively. The median seizure time of the patients was 120 seconds. There was no difference regarding ECG parameters among seizure types. Among the AED groups, Tp-e interval (P = 0.028), Tp-e/QT (P = 0.007), and Tp-e/QTd (P = 0.001) values were lower in those receiving lamotrigine. Conclusion: It was determined that there were differences in cardiac repolarization parameters between AEDs. Lamotrigine had the highest confidence interval due to its low effect on the ECG and low potential to cause arrhythmia. © 2025 Nigerian Journal of Clinical Practice.
dc.identifier.doi10.4103/njcp.njcp_488_24
dc.identifier.endpage1363
dc.identifier.issn1119-3077
dc.identifier.issue12
dc.identifier.pmid40033528
dc.identifier.scopus2-s2.0-86000140136
dc.identifier.scopusqualityQ2
dc.identifier.startpage1358
dc.identifier.urihttps://doi.org/10.4103/njcp.njcp_488_24
dc.identifier.urihttps://hdl.handle.net/20.500.12899/4980
dc.identifier.volume27
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.ispartofNigerian Journal of Clinical Practice
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_Scopus_20260612
dc.subjectAntiepileptic Drugs
dc.subjectEcg
dc.subjectEpilepsy
dc.subjectSeizure
dc.titleInvestigation of Electrocardiographic Changes Caused by Antepileptic Drugs in Epilepsy Patients
dc.typeArticle

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