Evaluation of hepatic steatosis in obese children and adolescents using immune-inflammatory markers and shear wave elastography

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dc.contributor.authorAkcicek, Mehmet
dc.contributor.authorDag, Nurullah
dc.date.accessioned2026-06-19T06:38:09Z
dc.date.available2026-06-19T06:38:09Z
dc.date.issued2025
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractAim To investigate the changes in liver stiffness and immune-inflammatory markers associated with obesity and the degree of hepatic steatosis in obese children and adolescents. Methods A total of 76 obese children and adolescents aged 6-18 years, with body mass index percentiles >95th, were included in the study. Patients with metabolic syndrome, diabetes mellitus, and chronic liver disease were excluded. A control group of 44 patients of healthy and normal-weight children was included. Laboratory values from the past month were analyzed using patient records. Shear wave elastography and ultrasound examinations were performed on a single device by the same experienced radiologist. Results The systemic immune-inflammation index and pan-immune inflammation values were significantly higher in obese patients with hepatic steatosis compared to obese patients without hepatic steatosis (p <0.001). Liver stiffness values were significantly higher in steatotic patients compared to nonsteatotic patients (p <0.001). A significant difference was observed between hepatic steatosis grades in terms of immune-inflammation index and pan-immune inflammation value values (p <0.001). There was a strong, positive, statistically significant correlation between liver stiffness and immune-inflammation index and pan-immune inflammation value (p <0.05). Conclusions Immune-inflammatory biomarkers and shear wave elastography may provide valuable insights into the diagnosis and follow-up of inflammation and fibrosis in the evaluation of hepatic steatosis in obese children and adolescents.
dc.identifier.doi10.15557/jou.2025.0001
dc.identifier.issn2084-8404
dc.identifier.issn2451-070X
dc.identifier.issue100
dc.identifier.orcid0000-0002-9342-0244
dc.identifier.orcid0000-0002-0232-1284
dc.identifier.pmid39882078
dc.identifier.scopus2-s2.0-85218141530
dc.identifier.scopusqualityQ3
dc.identifier.urihttps://doi.org/10.15557/jou.2025.0001
dc.identifier.urihttps://hdl.handle.net/20.500.12899/5415
dc.identifier.volume25
dc.identifier.wosWOS:001408568300001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSciendo
dc.relation.ispartofJournal of Ultrasonography
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260612
dc.subjectBiomarkers
dc.subjectElastography
dc.subjectLiver Steatosis
dc.titleEvaluation of hepatic steatosis in obese children and adolescents using immune-inflammatory markers and shear wave elastography
dc.typeArticle

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