Serum galectin-3 levels were associated with proteinuria in patients with Familial Mediterranean Fever

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dc.authoridDarcin, Tahir/0000-0001-5073-1790|Bilgic, Mukadder Ayse/0000-0003-0621-8273
dc.contributor.authorYilmaz, Hakki
dc.contributor.authorInan, Osman
dc.contributor.authorDarcin, Tahir
dc.contributor.authorBilgic, Mukadder Ayse
dc.contributor.authorAkcay, Ali
dc.date.accessioned2025-10-24T18:08:49Z
dc.date.available2025-10-24T18:08:49Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractThe most common and pernicious complication of Familial Mediterranean fever (FMF) is renal amyloidosis, usually affecting the kidneys, leading to end-stage renal failure. FMF-related renal amyloidosis needed to be diagnosed early. Optimal colchicine dose is effective in preventing and reversing renal amyloidosis. Galectin-3, profibrotic mediator, has regulatory functions in inflammation, fibrosis and tumorigenesis. Galectin-3 is a strong prognostic marker for heart failure. Galectin-3 plays role in diabetic nephropathy and chronic kidney disease. The aim of the study is to investigate whether galectin-3 is related to proteinuria and amyloidosis in FMF. Seventy-five FMF patients who have no exclusion criteria and healthy controls (n = 36) were included. Serum galectin-3 was measured and morning spot urine was collected for determination of the protein/creatinine ratio (PCR). Serum Galectin-3 levels were significantly higher in FMF patients than the control group [969.66 (3825) pg/mL vs. 238 (921) pg/mL, respectively; P < 0.001]. We classified into two groups: Group1 (n = 48) had FMF patients with proteniuria, Group2 (n = 27) had FMF patients without proteinuria. Group1 had higher levels of galectin-3 than Group2 [1106(3812) pg/mL vs. 867.3(1433) pg/mL, P < 0.001]. Galectin-3 levels were correlated with PCR in whole group and FMF group (r = 0.785, P < 0.001 and r = 0.803, P < 0.001). In ROC curve, best cutoff value = 581.50 pg/mL was used to detect proteinuria (sensitivity = 91.7 %, specificity = 71.4 %, AUC = 0.879) and optimal cutoff value = 1458.00 pg/mL was an indicator of nephrotic-range proteinuric (sensitivity = 100 %, specificity = 92.1 %, AUC = 0.983). Galectin-3 is associated with proteinuria and renal amyloidosis in FMF. Galectin-3 may play role in pathogenesis of amyloidosis.
dc.identifier.doi10.1007/s10157-014-1009-7
dc.identifier.endpage442
dc.identifier.issn1342-1751
dc.identifier.issn1437-7799
dc.identifier.issue3
dc.identifier.pmid25059227
dc.identifier.scopus2-s2.0-84931008889
dc.identifier.scopusqualityQ2
dc.identifier.startpage436
dc.identifier.urihttps://doi.org/10.1007/s10157-014-1009-7
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3326
dc.identifier.volume19
dc.identifier.wosWOS:000356249700015
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSpringer
dc.relation.ispartofClinical And Experimental Nephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectGalectin-3; Proteinuria; Renal amyloidosis; FMF
dc.titleSerum galectin-3 levels were associated with proteinuria in patients with Familial Mediterranean Fever
dc.typeArticle

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