Lower serotonin level and higher rate of fibromyalgia syndrome with advancing pregnancy

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dc.authoridKoc, Acar/0000-0003-2482-7478|NAMLI KALEM, MUBERRA/0000-0002-2316-5495|sonmez (atay), cigdem/0000-0001-9307-5674|Genc, Hakan/0000-0003-2573-4564|Yuce, Tuncay/0009-0008-6162-5748|Seval, Mehmet Murat/0000-0002-4922-5046
dc.contributor.authorAtasever, Melahat
dc.contributor.authorKalem, Muberra Namli
dc.contributor.authorSonmez, Cigdem
dc.contributor.authorSeval, Mehmet Murat
dc.contributor.authorYuce, Tuncay
dc.contributor.authorAker, Seda Sahin
dc.contributor.authorKoc, Acar
dc.date.accessioned2025-10-24T18:09:14Z
dc.date.available2025-10-24T18:09:14Z
dc.date.issued2017
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjective: The aim of the study is to investigate the relationship between changes in serotonin levels during pregnancy and fibromyalgia syndrome (FS) and the relationships between FS and the physical/psychological state, biochemical and hormonal parameters, which may be related to the musculoskeletal system.Study design: This study is a prospective case-control study conducted with 277 pregnant women at the obstetric unit of Ankara University Faculty of Medicine, in the period between January and June 2015. FS was determined based on the presence or absence of the 2010 ACR diagnostic criteria and all the volunteers were asked to answer the questionnaires as Fibromyalgia Impact Criteria (FIQ), Widespread Pain Index (WPI), Symptom Severity Scale (SS), Beck Depression Inventory and Visual Analog Scale (VAS). Biochemical and hormonal markers (glucose, TSH, T4, Ca (calcium), P (phosphate), PTH (parathyroid hormone) and serotonin levels) relating to muscle and bone metabolism were measured.Results: In the presence of fibromyalgia, the physical and psychological parameters are negatively affected (p<0.001). There was no significant difference between the fibromyalgia and control groups in terms of glucose, Ca (calcium), P (phosphorus), PTH (parathyroid hormone), TSH (thyroid stimulant hormone), fT4 (free T4) levels (p=0.060, 0.799, 0.074, 0.104, 0.797, 0.929, respectively). A reduction in serotonin levels may contribute to the development of fibromyalgia but this was not statistically significant. The Beck Depression Inventory scale statistically showed that increasing scores also increase the risk of fibromyalgia (p<0.001).Conclusion: Our study has shown that serotonin levels in women with FS are lower than the control group and that serotonin levels reduce as pregnancy progresses. Anxiety and depression in pregnant women with FS are higher than the control group. The presence of depression increases the likelihood of developing FS at a statistically significant level. Serotonin impairment also increases the chance of developing FS, but this correlation has not been shown to be statistically significant.
dc.identifier.doi10.1080/14767058.2016.1243096
dc.identifier.endpage2211
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue18
dc.identifier.pmid27696917
dc.identifier.scopus2-s2.0-84999767769
dc.identifier.scopusqualityQ1
dc.identifier.startpage2204
dc.identifier.urihttps://doi.org/10.1080/14767058.2016.1243096
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3543
dc.identifier.volume30
dc.identifier.wosWOS:000405217100012
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal Of Maternal-Fetal & Neonatal Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectPregnancy; fibromyalgia syndrome; serotonin
dc.titleLower serotonin level and higher rate of fibromyalgia syndrome with advancing pregnancy
dc.typeArticle

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