Oxygen regulated protein 150 can be considered as a severity indicator in obstructive sleep apnea

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dc.contributor.authorOtlu, Onder
dc.contributor.authorErdem, Mehmet
dc.contributor.authorKiran, Tugba Raika
dc.contributor.authorInceoglu, Feyza
dc.contributor.authorGeckil, Aysegul Altintop
dc.contributor.authorBerber, Nurcan Kirici
dc.contributor.authorIn, Erdal
dc.date.accessioned2026-06-19T06:39:35Z
dc.date.available2026-06-19T06:39:35Z
dc.date.issued2025
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractOxygen-regulated protein 150 (ORP150) is a chaperone found in the endoplasmic reticulum (ER) induced by ER stress, oxidative stress, glutamate toxicity, ischemia, and hypoxia. Increased expression of ORP150 protects the cells by stopping ER stress, maintaining calcium balance, and delaying apoptosis. In this study, we aim to investigate serum ORP150 amount in patients with different severity levels of obstructive sleep apnea (OSA). Forty-nine patients (25 of severe and 24 of mild-moderate), and 23 healthy controls were included in the study. Routine biochemical measurements and serum ORP150 measurements of all groups and sleep quality measurements of OSA groups were obtained. ELISA was used to measure ORP150 levels in serum samples. In addition, ROC analysis was performed to determine the diagnostic power of the ORP150 parameter. There are significant differences between all three groups in terms of ORP150 values (severe OSA: 8.03 +/- 0.4 ng/mL; mild-moderate OSA: 5.54 +/- 0.47 ng/mL; control: 4.41 +/- 0.25 ng/mL, p < 0.017). The highest ORP150 level belongs to the severe OSA group and there is a direct correlation between the severity of the disease and ORP150 levels. ORP150 value is a distinguishing parameter for OSA and the cut-off value of ORP150 was observed as 7.14 ng/mL. We concluded that serum ORP150 levels can be a differential diagnostic parameter in OSA patients and that disease severity can be determined by serum ORP150 measurement.
dc.identifier.doi10.1038/s41598-025-99987-6
dc.identifier.issn2045-2322
dc.identifier.issue1
dc.identifier.orcid0000-0001-5958-7609
dc.identifier.orcid0000-0003-1453-0937
dc.identifier.orcid0000-0002-8807-5853
dc.identifier.orcid0000-0002-9100-2479
dc.identifier.orcid0000-0002-3724-0249
dc.identifier.pmid40681769
dc.identifier.scopus2-s2.0-105010958289
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.1038/s41598-025-99987-6
dc.identifier.urihttps://hdl.handle.net/20.500.12899/5688
dc.identifier.volume15
dc.identifier.wosWOS:001532050200017
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherNature Portfolio
dc.relation.ispartofScientific Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260612
dc.subjectApnea-Hypopnea Index
dc.subjectObstructive Sleep Apnea
dc.subjectOxygen-Regulated Protein 150
dc.subjectPolysomnography
dc.subjectSleep Quality
dc.titleOxygen regulated protein 150 can be considered as a severity indicator in obstructive sleep apnea
dc.typeArticle

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