Significant correlation between serum DOTL1 levels and pain intensity, sensitivity, and psychological distress in women with fibromyalgia

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dc.contributor.authorErdem, Mehmet
dc.contributor.authorKiran, Tugba Raika
dc.contributor.authorOtlu, Onder
dc.contributor.authorBaykara, Rabia Aydogan
dc.contributor.authorInceoglu, Feyza
dc.date.accessioned2026-06-19T06:39:25Z
dc.date.available2026-06-19T06:39:25Z
dc.date.issued2025
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractDisruptor of telomeric silencing 1-like (DOT1L) is a protein involved in epigenetic regulation, as well as in the Wnt and hypoxia signaling pathways. DOT1L has been found to play a role in the pathogenesis of various diseases associated with these pathways. In this study, it was aimed to determine serum DOT1L levels in patients with fibromyalgia (FM) and its association with disease activity. Forty-eight patients diagnosed with FM according to the 2016 American College of Rheumatology criteria and 48 healthy controls were included in the study. Disease activity was measured using clinical questionnaires (Fibromyalgia Impact Questionnaire [FIQ], Visual Analog Scale [VAS], Widespread Pain Index [WPI], Symptom Severity Score [SSS], Pittsburgh Sleep Quality Index [PSQI], Fatigue Severity Scale [FSS], Hospital Anxiety Scale [HAS] and Hospital Depression Scale [HDS]) and DOT1L levels were assessed using Enzyme-Linked ImmunoSorbent Assay in all serum samples. Additionally, routine biochemical analyses were performed. Pain duration, FIQ, VAS, WPI, SSS, PSQI, FSS, HAS, and HDS were found to be statistically significant higher in FM compared to the control group (P = .001). Compared with the control group (0.53 +/- 0.12 ng/mL), DOT1L concentrations were significantly higher in patients with FM (1.47 +/- 0.13 ng/mL; P = .001). In the FM group, DOT1L levels also showed a positive correlation with the results of the all the clinical questionnaires (P = .001). It was found that the DOT1L measurement value has a statistically significant effect in predicting the difference between the FM and control groups (P = .022). When the cutoff value for DOT1L was set at 0.315 ng/mL, it was found to have 79% sensitivity and 71.7% specificity in detecting FM. This study highlights the potential of DOT1L as a valuable biomarker for FM diagnosis.
dc.identifier.doi10.1097/MD.0000000000041966
dc.identifier.issn0025-7974
dc.identifier.issn1536-5964
dc.identifier.issue12
dc.identifier.orcid0000-0003-1453-0937
dc.identifier.orcid0000-0002-3724-0249
dc.identifier.orcid0000-0002-9100-2479
dc.identifier.orcid0000-0001-5958-7609
dc.identifier.pmid40128062
dc.identifier.scopus2-s2.0-105001187095
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1097/MD.0000000000041966
dc.identifier.urihttps://hdl.handle.net/20.500.12899/5604
dc.identifier.volume104
dc.identifier.wosWOS:001450575800006
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherLippincott Williams & Wilkins
dc.relation.ispartofMedicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260612
dc.subjectBiomarker
dc.subjectDot1L
dc.subjectFibromyalgia
dc.subjectPain
dc.subjectSerum
dc.titleSignificant correlation between serum DOTL1 levels and pain intensity, sensitivity, and psychological distress in women with fibromyalgia
dc.typeArticle

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