Is There a Relationship Between Pelvic Organ Prolapse and Tissue Fibrillin-1 Levels?

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dc.authoridacar, muradiye/0000-0003-4357-5229;
dc.contributor.authorEser, Ayla
dc.contributor.authorUnlubilgin, Eylem
dc.contributor.authorHizli, Fatih
dc.contributor.authorAcar, Muradiye
dc.contributor.authorKamalak, Zeynep
dc.contributor.authorKosus, Aydin
dc.contributor.authorKosus, Nermin
dc.date.accessioned2025-10-24T18:10:09Z
dc.date.available2025-10-24T18:10:09Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractPurpose: Pelvic organ prolapse is a multifactorial disorder in which extracellular matrix defects are implicated. Fibrillin-1 level is reduced in stress urinary incontinence. In Marfan syndrome, which is associated with mutations in Fibrillin-1, pelvic floor disorders are commonly observed. We hypothesize that Fibrillin-1 gene expression is altered in pelvic organ prolapse. Methods: Thirty women undergoing colporrhaphy or hysterectomy because of cystocele, rectocele, cystorectocele, or uterine prolapse were assigned to a pelvic prolapse study group, and thirty women undergone hysterectomy for nonpelvic prolapse conditions were assigned to a control group. Real-time polymerase chain reaction was conducted on vaginal tissue samples to measure the expression of Fibrillin-1. Expression levels were compared between study and control groups by Mann-Whitney U test with Bonferroni revision. Results: Fibrillin-1 gene expression was not significantly lower in the study group than in the control group. Similarly, no significant correlation between Fibrillin-1 levels and grade of pelvic prolapse was found. Age over 40 years (P = 0.018) and menopause (P = 0.027) were both associated with reduced Fibrillin-1 levels in the pelvic prolapse group, whereas the delivery of babies weighing over 3,500 g at birth was associated with increased Fibrillin-1 expression (P = 0.006). Conclusions: The results did not indicate a significant reduction in Fibrillin-1 gene expression in pelvic prolapse disorders; however, reduced Fibrillin-1 may contribute to increased pelvic organ prolapse risk with age and menopause. Increased Fibrillin-1 gene expression may be a compensatory mechanism in cases of delivery of babies with high birth weight. Further studies are needed for a better understanding of these observations.
dc.description.sponsorshipTurgut Ozal University, Ankara, Turkey
dc.description.sponsorshipThis study was funded by the Turgut Ozal University, Ankara, Turkey.
dc.identifier.doi10.5213/inj.2015.19.3.164
dc.identifier.endpage170
dc.identifier.issn2093-4777
dc.identifier.issn2093-6931
dc.identifier.issue3
dc.identifier.pmid26620898
dc.identifier.scopus2-s2.0-84945583338
dc.identifier.scopusqualityQ2
dc.identifier.startpage164
dc.identifier.urihttps://doi.org/10.5213/inj.2015.19.3.164
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3997
dc.identifier.volume19
dc.identifier.wosWOS:000362389300007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKorean Continence Soc
dc.relation.ispartofInternational Neurourology Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectExtracellular Matrix; Fibrillin; Pelvic Organ Prolapse
dc.titleIs There a Relationship Between Pelvic Organ Prolapse and Tissue Fibrillin-1 Levels?
dc.typeArticle

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