Evaluation of bone metabolism in newborn twins using quantitative ultrasound and biochemical parameters

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dc.contributor.authorKara, Semra
dc.contributor.authorGuzoglu, Nilufer
dc.contributor.authorGocer, Emine
dc.contributor.authorArikan, Fatma Inci
dc.contributor.authorDilmen, Ugur
dc.contributor.authorBilge, Yildiz Dallar
dc.date.accessioned2025-10-24T18:09:45Z
dc.date.available2025-10-24T18:09:45Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractMetabolic bone disease (MBD) is one of the important complications of prematurity. Early and adequate nutritional interventions may reduce the incidence and potential complications of MBD. The present study aimed to evaluate bone metabolism in twins via biochemical parameters and quantitative ultrasound (QUS) and to compare the results between twin pairs. Moreover, twin infants were evaluated in terms of potential risk factors likely to have impact on MBD. Forty-three pairs of twins were included in the study. Serum calcium, phosphorus, magnesium, and alkaline phosphatase concentrations were assessed and bone mineral density was measured using QUS (speed of sound, SOS) at postnatal 30d. Co-twin with the higher birth weight was assigned to Group 1 (n=36) and the other twin was assigned to Group 2 (n=36). Birth weight and head circumference were significantly higher in the infants of Group 1 compared with Group 2. No significant difference was found among the groups in terms of gender, history of resuscitation, length of stay in intensive care unit (ICU) or in the incubator, duration of total parenteral nutrition (TPN), type of nutrition, vitamin D use, biochemical parameters, and the SOS value. The factors likely to affect SOS, including type of pregnancy, maternal drug use, gender of infant, birth weight, head circumference at birth, gestational week, length of stay at the ICU, duration of TPN, type of nutrition, resuscitation, vitamin D use, and levels of calcium, phosphorus, magnesium, and alkaline phosphatase were entered into the model. The phosphorus level and the maternal drug use were found to be the factors that significantly reduced SOS, whereas pregnancy after assisted reproductive techniques was found to be a significant enhancing factor.
dc.identifier.doi10.3109/14767058.2015.1025743
dc.identifier.endpage948
dc.identifier.issn1476-7058
dc.identifier.issn1476-4954
dc.identifier.issue6
dc.identifier.pmid25777793
dc.identifier.scopus2-s2.0-84949580174
dc.identifier.scopusqualityQ1
dc.identifier.startpage944
dc.identifier.urihttps://doi.org/10.3109/14767058.2015.1025743
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3804
dc.identifier.volume29
dc.identifier.wosWOS:000366322400017
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTaylor & Francis Ltd
dc.relation.ispartofJournal Of Maternal-Fetal & Neonatal Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectBone metabolism; quantitative ultrasound; twins
dc.titleEvaluation of bone metabolism in newborn twins using quantitative ultrasound and biochemical parameters
dc.typeArticle

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