Effects of intravenous ibuprofen and lornoxicam on erythrocyte deformability in rats undergoing hind limb ischemia reperfusion injury

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dc.authoridKucuk, Aysegul/0000-0001-9316-9574|AYDIN, Muhammed Enes/0000-0001-8491-6566|Arslan, Mustafa/0000-0003-4882-5063|ARPACI, AYSE HANDE/0000-0001-8159-4637
dc.contributor.authorSivgin, V
dc.contributor.authorKucuk, A.
dc.contributor.authorComu, F. M.
dc.contributor.authorKosem, B.
dc.contributor.authorKartal, S.
dc.contributor.authorTurgut, H. C.
dc.contributor.authorArpaci, H.
dc.date.accessioned2025-10-24T18:09:57Z
dc.date.available2025-10-24T18:09:57Z
dc.date.issued2016
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBACKGROUNDAND AIM: Acute hind limb ischemia reperfusion (I/R) injury is a common consequence of abdominal aorta cross-clamping during aortic surgery. Erythrocyte deformability is affected by I/R process and may lead to increased tissue and organ injury. Lornoxicam and intravenous ibuprofen are becoming commonly used as non-steroidal anti-inflammatory drugs (NSAID) for postoperative analgesia. In this study, we aimed to investigate the effects of lornoxicam (2 mg/kg iv) and intravenous ibuprofen (30 mg/kg iv) on erythrocyte deformability in I/R model in rats. MATERIALS AND METHODS: Four study groups, each containing 6 Wistar rats were created. Laparotomy was performed in all groups under general anesthesia with ketamine and xylazine. In all groups except sham group, ischemia and reperfusion were achieved by clamping and declamping the infrarenal abdominal aorta for 120 minutes. Rats in Group IR+L received intravenous infusion of lornoxicam (2 mg/kg) while rats in Group 1R+I received intravenous infusion of ibubrofen (30 mg/kg) following 2 hours of ischemic period. At the end of reperfusion period, erythrocyte packs were prepared from heparinized blood samples. Erythrocyte suspensions with hematocrit at a concentration of 5% in a phosphate-buffered saline (PBS) were used in order to perform deformability measurements. The value of p<0.05 was considered statistically significant. RESULTS: Relative resistance has increased in ischemia reperfusion group when compared to control group (p < 0.0001). Lornoxicam or ibuprofen intravenous treatments did not change the erythrocyte deformability during ischemia reperfusion period in rats (p=0.851, p=0.690). CONCLUSION: Intravenous ibuprofen or lornoxicam administrations during ischemia reperfusion period in rats have no negative effect on erythrocyte deformability. The findings of the study should be supported with more detailed and extensive clinical/experimental studies in the future (Fig. 1, Ref. 18). Text in PDF www.elis.sk.
dc.identifier.doi10.4149/BLL_2016_138
dc.identifier.endpage725
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue12
dc.identifier.pmid28127969
dc.identifier.scopus2-s2.0-85015083387
dc.identifier.scopusqualityQ2
dc.identifier.startpage722
dc.identifier.urihttps://doi.org/10.4149/BLL_2016_138
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3902
dc.identifier.volume117
dc.identifier.wosWOS:000392564800007
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherComenius Univ
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listy
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectischemia reperfusion; erythrocyte deformability; intravenous ibuprofen; lornoxicam; rat
dc.titleEffects of intravenous ibuprofen and lornoxicam on erythrocyte deformability in rats undergoing hind limb ischemia reperfusion injury
dc.typeArticle

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