Diagnostic Value of Galectin-3 in Exacerbations of Chronic Obstructive Pulmonary Disease

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dc.contributor.authorBerber, Nurcan Kirici
dc.contributor.authorAtli, Siahmet
dc.contributor.authorGeckil, Ayseguel Altintop
dc.contributor.authorErdem, Mehmet
dc.contributor.authorKiran, Tugba Raika
dc.contributor.authorOtlu, Onder
dc.contributor.authorIn, Erdal
dc.date.accessioned2026-06-19T06:37:42Z
dc.date.available2026-06-19T06:37:42Z
dc.date.issued2024
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground and Objectives: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease characterized by acute exacerbations. Systemic inflammation and oxidative stress play an important role in the pathogenesis of COPD. Exacerbations in COPD reduce the quality of life and are associated with rapid disease progression. Galectin-3 is a beta-galactoside-binding lectin of approximately 30 kDa with pro-inflammatory and pro-fibrotic properties. This study aims to analyze the efficacy of serum galectin-3 in predicting exacerbations in COPD patients. Materials and Methods: Baseline demographic and clinical characteristics of all patients were recorded and blood samples were collected. A total of 58 consecutive COPD patients, including 28 patients (19 male and 9 female) with stable COPD and 30 patients (23 male and 7 female) with acute exacerbation of COPD (AECOPD), were included in the study. Results: Serum galectin-3 levels were significantly higher in the AECOPD group compared to the stable COPD group. A logistic regression analysis revealed that increased galectin-3 levels and disease duration were independent predictors of COPD exacerbation (OR = 5.322, 95% CI: 1.178-24.052, p = 0.03; and OR = 1.297, 95% CI: 1.028-1.635, p = 0.028; respectively). Conclusions: The results of our study demonstrated that Galectin-3 was a strong and independent predictor of exacerbations in COPD patients.
dc.identifier.doi10.3390/medicina60040529
dc.identifier.issn1010-660X
dc.identifier.issn1648-9144
dc.identifier.issue4
dc.identifier.orcid0000-0002-3724-0249
dc.identifier.orcid0000-0001-6283-181X
dc.identifier.pmid38674175
dc.identifier.scopus2-s2.0-85191295822
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/medicina60040529
dc.identifier.urihttps://hdl.handle.net/20.500.12899/5176
dc.identifier.volume60
dc.identifier.wosWOS:001209939500001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofMedicina-Lithuania
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260612
dc.subjectChronic Obstructive Pulmonary Disease
dc.subjectAcute Exacerbation
dc.subjectGalectin-3
dc.subjectBiomarker
dc.subjectSystemic Inflammation
dc.titleDiagnostic Value of Galectin-3 in Exacerbations of Chronic Obstructive Pulmonary Disease
dc.typeArticle

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