Gaviscon and domperidon responsive apnea episodes associated with gastro-esophageal reflux disease in twins

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dc.contributor.authorBilgin, Huseyin
dc.contributor.authorEren, Abdulkadir
dc.contributor.authorKara, Semra
dc.date.accessioned2025-10-24T18:10:13Z
dc.date.available2025-10-24T18:10:13Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground: The possible pathophysiology of the relationship between gastro-esophageal reflux disease and apnea of prematurity has been widely investigated. Various physiological protective reflex responses provide a plausible biological link between gastro-esophageal reflux and apnea of prematurity. It is uncertain whether or not there is a causal relationship between the two diseases. Patient's Findings: Twins were admitted to the neonatal intensive care unit due to feeding problems. Physical examination was normal except for reticulated, blue-violet skin changes. Short apneic attacks occurred on the first day in twin 1 and on the second day in twin 2, and these were initially treated by stimulation and increased ambient O-2 concentration. Then, we conducted methylxanthine and continuous positive airway pressure treatment. Laboratory and radiological analysis were normal. As gastro-esophageal reflux disease was thought to be the causes of the treatment-refractory apnea, therapy with gaviscon and domperidon was begun for both cases. Apneic attacks did not recur after gaviscon and domperidon therapy. Conclusion: Pharmacological therapy for gastro-esophageal reflux disease has not definitively been shown to be effective in improving symptoms and hence, should be reserved especially for infants with treatment refractory apnea episodes suspected as being gastro-esophageal reflux in premature infants.
dc.identifier.doi10.6133/apjcn.2015.24.4.12
dc.identifier.endpage755
dc.identifier.issn0964-7058
dc.identifier.issn1440-6047
dc.identifier.issue4
dc.identifier.pmid26693761
dc.identifier.scopus2-s2.0-84983611288
dc.identifier.scopusqualityQ2
dc.identifier.startpage753
dc.identifier.urihttps://doi.org/10.6133/apjcn.2015.24.4.12
dc.identifier.urihttps://hdl.handle.net/20.500.12899/4050
dc.identifier.volume24
dc.identifier.wosWOS:000368049500023
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherH E C Press, Healthy Eating Club Pty Ltd
dc.relation.ispartofAsia Pacific Journal Of Clinical Nutrition
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectapnea; gastro esophageal reflux disease; premature; newborn; treatment
dc.titleGaviscon and domperidon responsive apnea episodes associated with gastro-esophageal reflux disease in twins
dc.typeArticle

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