mTOR signaling pathway genes effect in COVID-19 infection

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dc.contributor.authorPala, Mukaddes
dc.contributor.authorYılmaz, Şenay Görücü
dc.contributor.authorTanriverdi, Elif Seren
dc.contributor.authorGunduz, Ayten
dc.contributor.authorDelen, Leman Acun
dc.contributor.authorOzturk, Dilara Altay
dc.contributor.authorÖterkuş, Mesut
dc.date.accessioned2025-10-24T17:59:23Z
dc.date.available2025-10-24T17:59:23Z
dc.date.issued2024
dc.departmentMalatya Turgut Özal Üniversitesi
dc.descriptionProject No:2021/7
dc.description.abstractCoronavirus disease 2019 (Covid-19) is an infectious disease that causes severe acute respiratory illness caused by coronavirus 2 (SARS-CoV-2). SARS-CoV-2 uses host-specific metabolic pathways, including mTOR. The mTOR pathway is hyperactive in viral respiratory tract infections and contributes positively to viral replication. 100 samples were evaluated, 50 patients (Female=23, Male=27), and 50 controls (Female=29, Male=21). The patients were individuals who were COVID-19 positive. We detected expression changes of 5 genes in mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2) (MLST8, mTOR, RPTOR, MAPKAP1 and RICTOR). Serum samples were obtained from all patients. The expression changes of mTORC1 and mTORC2 Complex genes were evaluated with Real-time PCR method. Receiver operating curve (ROC) analysis was performed to define the diagnostic power of these genes. Expression changes of five genes in the mTORC1 and mTORC2 complex were statistically significant (p =0.001) and upregulated in serum. The area under the ROC Curve values indicating the diagnostic power of genes were 0.948, 0.771, 0.851, 0.798, and 0.805, respectively. These genes may be candidate for treatment targets. The high discriminative power of these genes in patients from controls indicates their diagnostic potential in serum samples.
dc.description.sponsorship[EN] Malatya Turgut Ozal University
dc.identifier.endpage206
dc.identifier.issn2980-0463
dc.identifier.issue2
dc.identifier.startpage191
dc.identifier.urihttps://hdl.handle.net/20.500.12899/2109
dc.identifier.volume3
dc.language.isoen
dc.publisherInonu University
dc.relation.ispartofAnatolian Journal of Pharmaceutical Sciences
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzDergiPark_20251023
dc.subjectGene Expression
dc.subjectGen İfadesi
dc.titlemTOR signaling pathway genes effect in COVID-19 infection
dc.typeArticle

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