Relationship of galectin-3 to left ventricular geometry and hypertrophy in chronic hemodialysis patients

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dc.authoridYILDIRIM, MEHMET/0000-0003-4768-4537|Bilgic, Celal Ismail/0000-0003-0434-8672|Bilgic, Mukadder Ayse/0000-0003-0621-8273
dc.contributor.authorYilmaz, H.
dc.contributor.authorGurel, O. M.
dc.contributor.authorCelik, H. T.
dc.contributor.authorBozkurt, A.
dc.contributor.authorYildirim, M. E.
dc.contributor.authorBilgic, I.
dc.contributor.authorBilgic, M. A.
dc.date.accessioned2025-10-24T18:08:47Z
dc.date.available2025-10-24T18:08:47Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractAim and background. Galectin-3 (Gal-3) is used to determine the prognosis of heart failure. Some studies revealed that Gal-3 promoted cardiac hypertrophy but there is no study in which the relationship between -Gal-3 and left ventricular hypertrophy (LVH) geometry in patients without diastolic and systolic function impairment has been explored. The aim of the study was to analyze associations between plasma Gal-3 levels, LVH, and LV geometry in maintenance hemodialysis (HD) patients without systolic and diastolic dysfunction. Patients and methods. The study group included 105 patients (53 women and 52 men)-with an average age of 58.2+/-12.6 years, treated with HD for an average of 45+/-32 months-and 60 healthy controls. The Gal-3 and other biochemical parameters were measured and color Doppler echocardiography was performed. For this study LVH was considered present when the LV mass index (LVMI) exceeded 95 g/m(2) in women and 115 g/m(2) in men. Left ventricular geometry was classified into the four groups on the basis of left ventricular mass and relative wall thickness (RWT). Results. Concentric hypertrophy (CH, 40.9%, n= 43) was the commonest geometric pattern in our study. The Gal-3 levels in CH patients were not different from the patients with eccentric hypertrophy (EH). Plasma levels of Gal-3 correlated with LVMI (r= 0.617, p< 0.001), parathyroid hormone (PTH, r= 0.408, p< 0.001), uric acid (r= 0.281, p = 0.004), C-reactive protein (CRP, r= 0.412, p< 0.001), and RWT (r= 0.281, p = 0.004) but were inversely correlated with albumin (r=-0.466, P< 0.001) in the whole group. Plasma levels of Gal-3 were associated with LVMI (r= 0.812, P< 0.001), RWT (r= 0.318, p = 0.001), and CRP(r= 0.381, p< 0.001) in maintenance hemodialysis patients. Conclusion. The Gal-3 level is related to left ventricular hypertrophy and it is independent of left ventricle geometry. The relationship between LVH and Gal-3 might be direct or it may also be inflammation-related.
dc.identifier.doi10.1007/s00059-014-4111-4
dc.identifier.endpage708
dc.identifier.issn0340-9937
dc.identifier.issn1615-6692
dc.identifier.issue4
dc.identifier.pmid24924396
dc.identifier.scopus2-s2.0-84931007783
dc.identifier.scopusqualityQ3
dc.identifier.startpage702
dc.identifier.urihttps://doi.org/10.1007/s00059-014-4111-4
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3295
dc.identifier.volume40
dc.identifier.wosWOS:000356266000030
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherUrban & Vogel
dc.relation.ispartofHerz
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.snmzKA_20251023
dc.subjectGalectin 3; Left ventricular hypertrophy; Left ventricular geometry; Hemodialysis; End-stage renal disease
dc.titleRelationship of galectin-3 to left ventricular geometry and hypertrophy in chronic hemodialysis patients
dc.title.alternativeBeziehung von Galectin-3 zu linksventrikulärer Geometrie und Hypertrophie bei chronischen Hämodialysepatienten
dc.typeArticle

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