The Role of the Low-Density Lipoprotein/High-Density Lipoprotein Cholesterol Ratio as an Atherogenic Risk Factor in Young Adults with Ischemic Stroke: A Case-Control Study

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dc.authoridAdiguzel, Ahmet/0000-0001-5197-7063|Ciplak, Sibel/0000-0002-2304-8125;
dc.contributor.authorCiplak, Sibel
dc.contributor.authorAdiguzel, Ahmet
dc.contributor.authorDeniz, Yusuf Ziya
dc.contributor.authorAba, Melike
dc.contributor.authorOzturk, Unal
dc.date.accessioned2025-10-24T18:09:46Z
dc.date.available2025-10-24T18:09:46Z
dc.date.issued2023
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractDyslipidemia is a major atherogenic risk factor for ischemic stroke. Stroke patients tend to have high levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) and low levels of high-density lipoprotein cholesterol (HDL-C). Therefore, it is noteworthy that there has been an increase in ischemic stroke cases in young and elderly individuals in recent years. This study investigated the TC/HDL-C ratio and the LDL-C/HDL-C ratio, which may be more specific and common lipid parameters in young patients with ischemic stroke. This study aimed to demonstrate the sensitivity and specificity of TC/HDL-C and LDL-C/HDL-C ratios as atherogenic markers for young adult ischemic strokes. This trial was conducted as a retrospective case-control study. A total of 123 patients (patient group) and 86 healthy individuals (control group) aged 18-50 years were randomly selected from four different hospitals. Lipid parameters and TC/HDL-C and LDL-C/HDL-C ratios were compared between these two groups. The mean age was 38.8 +/- 7.3 years in patients and 37.7 +/- 9 years in controls (p > 005). The HDL-C levels were 39.1 +/- 10.8 mg/dL in patients and 48.4 +/- 13.8 mg/dL in controls (p < 0.001). LDL-C/HDL-C ratios were 3.23 +/- 1.74 and 2.38 +/- 0.87, and TC/HDL-C ratios were 5.24 +/- 2.31 and 4.10 +/- 1.25 in the patient and control groups, respectively (p < 0.001). The LDL-C/HDL-C and TC/HDL-C cutoff values in ROC analyses were 2.61 and 4.40 respectively; the AUCs (95% CI) were determined to be 0.680 (0.608-0.753) and 0.683 (0.610-0.755) (p < 0.001), respectively. An increased risk of stroke was observed in those with a high LDL-C/HDL-C ratio (OR = 1.827; 95% CI = 1.341-2.488; p < 0.001). Our study obtained similar results when we compared the mean TC and LDL-C levels between the two groups. However, considering the TC/HDL-C and LDL-C/HDL-C ratios, it is noteworthy that there was a significant difference between the patient and control groups.
dc.description.sponsorshipInfinite gratitude and warm regards to Nusret Ayaz, a graduate of the Faculty of Medicine at Uludag University in 2010.; Faculty of Medicine at Uludag University
dc.description.sponsorshipInfinite gratitude and warm regards to Nusret Ayaz, a graduate of the Faculty of Medicine at Uludag University in 2010.
dc.identifier.doi10.3390/brainsci13081180
dc.identifier.issn2076-3425
dc.identifier.issue8
dc.identifier.pmid37626536
dc.identifier.urihttps://doi.org/10.3390/brainsci13081180
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3818
dc.identifier.volume13
dc.identifier.wosWOS:001055360000001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofBrain Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectischemic stroke; LDL-C/HDL-C; atherosclerosis; hyperlipidemia; cholesterol
dc.titleThe Role of the Low-Density Lipoprotein/High-Density Lipoprotein Cholesterol Ratio as an Atherogenic Risk Factor in Young Adults with Ischemic Stroke: A Case-Control Study
dc.typeArticle

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