Brain-derived neurotrophic factor is increased in serum levels of patients with symptomatic dermographism

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dc.authoridBozkurt, Bulent/0000-0003-4764-3735;
dc.contributor.authorErpolat, Seval
dc.contributor.authorCelik, Huseyin Tugrul
dc.contributor.authorBozkurt, Bulent
dc.date.accessioned2025-10-24T18:10:02Z
dc.date.available2025-10-24T18:10:02Z
dc.date.issued2017
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractIntroduction: Symptomatic dermographism (SD) is the most common form of physical urticaria. However, the role of neuroimmune mechanisms in SD is unclear. Aim: To investigate circulating levels of brain-derived neurotrophic factor (BDNF) in symptomatic dermographism. Material and methods: Thirty-two patients suffering from SD and 33 healthy subjects were included in the study. Serum BDNF levels were determined by a human enzyme-linked immunoassay (ELISA) kit. The serum C-reactive protein concentration and eosinophil counts in peripheral blood were evaluated. Results: The BDNF serum levels were detectable in both SD patients and healthy controls. The BDNF serum levels were significantly higher in patients with SD compared with healthy controls (p = 0.004). There was a positive but weak correlation between serum BDNF and CRP levels; it was not statistically significant (r = 0.211, p = 0.255). There was also a positive but weak correlation between serum BDNF and eosinophil counts; it was not statistically significant (r = 0.271, p = 0.141). Conclusions: The present study shows that BDNF is increased in the serum levels of patients with SD, suggesting a role for BDNF in the pathophysiology of this disorder.
dc.identifier.doi10.5114/ada.2017.69315
dc.identifier.endpage349
dc.identifier.issn1642-395X
dc.identifier.issue4
dc.identifier.pmid28951710
dc.identifier.scopus2-s2.0-85026665048
dc.identifier.scopusqualityQ2
dc.identifier.startpage346
dc.identifier.urihttps://doi.org/10.5114/ada.2017.69315
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3955
dc.identifier.volume34
dc.identifier.wosWOS:000408254400010
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTermedia Publishing House Ltd
dc.relation.ispartofPostepy Dermatologii I Alergologii
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectsymptomatic dermographism; brain-derived neurotrophic factor; neurotrophin
dc.titleBrain-derived neurotrophic factor is increased in serum levels of patients with symptomatic dermographism
dc.typeArticle

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