The effects of ankaferd blood stopper and microporous polysaccharide hemospheres on epidural fibrosis in rat laminectomy model

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dc.contributor.authorÖzay, Rafet
dc.contributor.authorYavuz, Osman Yùksel
dc.contributor.authorTürkoğlu, Erhan
dc.contributor.authorAktaş, Abit
dc.contributor.authorYiğit, Funda
dc.contributor.authorÖzdemir, Hacı Mustafa
dc.contributor.authorŞekerci, Zeki
dc.date.accessioned2025-10-24T18:06:43Z
dc.date.available2025-10-24T18:06:43Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractPURPOSE: To investigate whether topically administered hemostatic agents ankaferd blood stopper and microporous polysaccharide hemospheres can decrease epidural fibrosis after laminectomy in rats. METHODS: Eighteen adult male Sprague-Dawley rats were equally and randomly divided into three groups. In the treatment groups, ankaferd blood stopper and microporous polysaccharide hemospheres topically administrated upon duramater surface after laminectomy. Fibroblast count, epidural fibrosis and arachnoidal involvement were evaluated and graded histopathologically. RESULTS: Our data revealed that the count of fibroblasts, the grading of epidural fibrosis and arachnoideal involvement in the rats treated with microporous polysaccharide hemospheres were significantly less than the control group. Although the arachnoideal involvement in ankaferd blood stopper group were significantly less than the control group, there were no statistical differences when comparing the grading of epidural fibrosis and the fibroblasts count between the treatment groups and the control group. CONCLUSION: The ankaferd blood stopper and microporous polysaccharide hemospheres reduced epidural fibrosis and arachnoideal involvement after laminectomy in rats. © 2016 Elsevier B.V., All rights reserved.
dc.identifier.doi10.1590/S0102-865020150120000002
dc.identifier.endpage805
dc.identifier.issn1678-2674
dc.identifier.issn0102-8650
dc.identifier.issue12
dc.identifier.pmid26735050
dc.identifier.scopus2-s2.0-84954428790
dc.identifier.scopusqualityQ2
dc.identifier.startpage799
dc.identifier.urihttps://doi.rog/10.1590/S0102-865020150120000002
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3166
dc.identifier.volume30
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherSociedade Brasileira para o Desenvolvimento de Pesquisa em Cirurgia sgolden@terra.com.br
dc.relation.ispartofActa Cirurgica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzScopus_20251023
dc.subjectFibrosis
dc.subjectHemostasis
dc.subjectLaminectomy
dc.subjectPolysaccharides
dc.subjectRats
dc.titleThe effects of ankaferd blood stopper and microporous polysaccharide hemospheres on epidural fibrosis in rat laminectomy model
dc.typeArticle

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