Pre-earthquake kidney function is a predictor of outcomes in earthquake-related crush syndrome

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dc.authoridKoksal Cevher, Simal/0000-0001-6502-2399;
dc.contributor.authorDanis, Ramazan
dc.contributor.authorOzturk, Savas
dc.contributor.authorKocyigit, Ismail
dc.contributor.authorKilic, Jehat
dc.contributor.authorCivan, Merve
dc.contributor.authorSahutoglu, Tuncay
dc.contributor.authorTorun, Dilek
dc.date.accessioned2025-10-24T18:09:33Z
dc.date.available2025-10-24T18:09:33Z
dc.date.issued2025
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground The devastating earthquakes in Kahramanmara & scedil;, T & uuml;rkiye, in February 2024, caused extensive trauma and loss of lives, causing unique challenges in the management of earthquake-related crush syndrome. The current study investigates the prognostic value of pre-earthquake kidney function for mortality prediction in patients diagnosed with crush syndrome. Methods A multi-center retrospective analysis was performed using data from 469 patients treated at 46 nephrology clinics. Pre-earthquake Kidney function, defined by serum creatinine and estimated glomerular filtration rate (eGFR) levels, was obtained from pre-earthquake health records. Clinical findings, laboratory parameters, complications, and survival probabilities were analyzed. Multivariate Cox regression was used to identify independent predictors of in-hospital mortality. Results The mean age of participants was 42.56 +/- 16.92 years (Non-survivors: 50.46 +/- 20.03 years, Survivors: 42.34 +/- 16.80 years (p = 0.172)). The in-hospital mortality rate was 2.8%. Non-survivors exhibited significantly higher pre-earthquake creatinine levels than survivors (1.04 +/- 0.61 mg/dL vs. 0.77 +/- 0.33 mg/dL, p = 0.03), with lower eGFR (85.2 +/- 34.7 mL/min/1.73 m(2 )vs. 115.8 +/- 39.4 mL/min/1.73 m(2 ), p = 0.008). Compared with survivors, non-survivors had higher incidences of AKI (92.3% vs. 61.6%, p = 0.037) and more severe metabolic disturbances, including hyperkalemia (5.41 +/- 1.72 mmol/L vs. 5.13 +/- 0.98 mmol/L, p = 0.008). Regression analysis revealed that pre-earthquake creatinine (HR: 9.121, 95% CI: 2.686-30.970, p < 0.001) and potassium levels at admission (HR: 3.338, 95% CI: 1.540-7.232, p = 0.002) were independent predictors of mortality. Conclusions Pre-earthquake kidney function significantly predicts mortality in crush syndrome patients, highlighting the importance of baseline kidney assessment in disaster preparedness.
dc.identifier.doi10.1186/s12882-025-04183-3
dc.identifier.issn1471-2369
dc.identifier.issue1
dc.identifier.pmid40484930
dc.identifier.urihttps://doi.org/10.1186/s12882-025-04183-3
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3700
dc.identifier.volume26
dc.identifier.wosWOS:001504529400001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBmc
dc.relation.ispartofBmc Nephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectCrush syndrome; kidney function; mortality; disaster nephrology; acute kidney injury; hyperkalemia; T & uuml;rkiye
dc.titlePre-earthquake kidney function is a predictor of outcomes in earthquake-related crush syndrome
dc.typeArticle

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