Malondialdehyde and nitric oxide levels and catalase, superoxide dismutase, and glutathione peroxidase levels in maternal blood during different trimesters of pregnancy and in the cord blood of newborns

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dc.authoridYigit, Ayse Arzu/0000-0001-5837-6877;
dc.contributor.authorYuksel, Sevda
dc.contributor.authorYigit, Ayse Arzu
dc.date.accessioned2025-10-24T18:09:52Z
dc.date.available2025-10-24T18:09:52Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground/aim: To determine whether levels of malondialdehyde (MDA), nitric oxide (NO), superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) change during the 3 trimesters of pregnancy, and to compare the third trimester of pregnancy with newborn cord blood in respect to the levels of MDA, NO, and antioxidant enzymes. Materials and methods: Maternal blood samples were collected at 9-13, 22-26, and 36-40 weeks of gestation. Cord blood was collected at the time of delivery. Results: NO levels and GPx activity were higher in the second and third trimesters than in the first trimester. MDA level was lower in the third trimester and SOD and CAT activities were lower in the second and third trimesters than the first trimester. In cord blood, MDA and NO levels were lower while CAT and GPx activities were higher than in the third trimester of pregnancy. Conclusion: These results suggest that the balance of free radical and antioxidant production during pregnancy ensures healthy fetus growth and development.
dc.description.sponsorshipKirikkale University Research Fund [2010/1]
dc.description.sponsorshipThis study was summarized from a PhD thesis with the same title written by Sevda Yuksel. The work in this study was supported by the Kirikkale University Research Fund, Project No. 2010/1.
dc.identifier.doi10.3906/sag-1311-72
dc.identifier.endpage459
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue2
dc.identifier.pmid26084141
dc.identifier.scopus2-s2.0-84926362363
dc.identifier.scopusqualityQ1
dc.identifier.startpage454
dc.identifier.urihttps://doi.org/10.3906/sag-1311-72
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3869
dc.identifier.volume45
dc.identifier.wosWOS:000352482000030
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherTubitak Scientific & Technological Research Council Turkey
dc.relation.ispartofTurkish Journal Of Medical Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectMaternal blood; catalase; cord blood; glutathione peroxidase; malondialdehyde; nitric oxide; superoxide dismutase
dc.titleMalondialdehyde and nitric oxide levels and catalase, superoxide dismutase, and glutathione peroxidase levels in maternal blood during different trimesters of pregnancy and in the cord blood of newborns
dc.typeArticle

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