Unveiling the significance of Netrin-1 and Netrin-4 in metabolic syndrome

Basit Öğe Kaydı
dc.contributor.authorKiran, Tugba Raika
dc.contributor.authorAyyildiz, Gamze
dc.contributor.authorKeskin, Lezan
dc.contributor.authorErdem, Mehmet
dc.date.accessioned2026-06-19T06:39:34Z
dc.date.available2026-06-19T06:39:34Z
dc.date.issued2026
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractMetabolic syndrome (MetS) is characterized by insulin resistance, dyslipidemia, hyperglycemia, and chronic low-grade inflammation. This study aimed to evaluate serum levels of Netrin-1 (NTN1) and Netrin-4 (NTN4) in individuals with MetS and to explore their associations with metabolic and inflammatory parameters. Forty patients with MetS (diagnosed according to the NCEP ATP III criteria) and forty age- and sex-matched healthy controls were included. Serum NTN1 and NTN4 concentrations were measured using enzyme-linked immunosorbent assay (ELISA), together with biochemical and hematological analyses. MetS patients exhibited significantly higher NTN1 (146.66 (54.79) pg/mL) and NTN4 (176.76 +/- 41.65 pg/mL) levels than controls (110.343 (27.14) pg/mL and 133.10 +/- 32.17 pg/mL, respectively; p = 0.001). Binary logistic regression identified NTN4 as a significant variable associated with MetS (p = 0.017), whereas NTN1 did not remain significant after adjustment for other factors. Both markers showed positive correlations with body mass index, fasting glucose, HbA1c, triglycerides, and CRP, and negative correlations with HDL cholesterol (p = 0.001). Receiver operating characteristic (ROC) analysis identified optimal cut-off values for discriminating MetS, with NTN1 >= 122.99 pg/mL yielding 82.5% sensitivity and NTN4 >= 186.49 pg/mL showing 97.5% specificity. Elevated NTN1 and NTN4 levels were associated with the metabolic and inflammatory alterations characteristic of MetS. NTN4, and to a lesser extent NTN1, were associated with systemic metabolic imbalance.
dc.description.sponsorshipScientific Research Projects Coordination Unit of Malatya Turgut zal University, Turkey [Grant number 2023/23Y04]
dc.description.sponsorshipThis study was supported by a grant from the Scientific Research Projects Coordination Unit of Malatya Turgut Ozal University, Turkey [Grant number 2023/23Y04].
dc.identifier.doi10.1038/s41598-026-36172-3
dc.identifier.issn2045-2322
dc.identifier.issue1
dc.identifier.pmid41559306
dc.identifier.scopus2-s2.0-105029770549
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://doi.org/10.1038/s41598-026-36172-3
dc.identifier.urihttps://hdl.handle.net/20.500.12899/5687
dc.identifier.volume16
dc.identifier.wosWOS:001688974600020
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherNature Portfolio
dc.relation.ispartofScientific Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260612
dc.subjectNetrin-1
dc.subjectNetrin-4
dc.subjectMetabolic Syndrome
dc.subjectInsulin Resistance
dc.subjectBiomarkers
dc.titleUnveiling the significance of Netrin-1 and Netrin-4 in metabolic syndrome
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu