Clinical Heterogeneity of Major Depressive Disorder: The Role of Trauma, Dissociation, and Sleep

Basit Öğe Kaydı
dc.contributor.authorNamli, Zeynep
dc.contributor.authorTamam, Lut
dc.contributor.authorDemirkol, Mehmet Emin
dc.contributor.authorKaraytug, Mahmut Onur
dc.contributor.authorYesiloglu, Caner
dc.contributor.authorCetin Demirtas, Sinem
dc.contributor.authorUgur, Kerim
dc.date.accessioned2026-06-19T06:37:43Z
dc.date.available2026-06-19T06:37:43Z
dc.date.issued2026
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground: Major depressive disorder (MDD) is a common mental disorder characterized by a wide range of symptoms and a substantial contribution to global disease burden. Our study aimed to examine the relationships between childhood trauma, sleep quality, dissociative symptoms, posttraumatic growth, and suicidality in patients diagnosed with MDD. Methods: Our sample consisted of 115 patients with MDD and 84 healthy controls. Participants were administered the Hamilton Depression Rating Scale (HDRS), Beck Scale for Suicidal Ideation (BSSI), Pittsburgh Sleep Quality Index (PSQI), Childhood Trauma Questionnaire (CTQ-33), Dissociative Experiences Scale (DES), and Posttraumatic Growth Inventory (PTGI). Group differences were analyzed, and associations among variables within the MDD group were examined using correlation and mediation analyses. Results: Compared to healthy controls, patients with MDD had significantly higher scores on all scales except the PTGI (p < 0.001 for each). Within the MDD group, individuals with a history of suicide attempts had significantly higher CTQ total scores, physical and sexual abuse subscale scores, and DES scores than those without previous attempts. Additionally, dissociative experiences had a partial mediating role in the relationship between depression severity and suicidal ideation, as well as in the relationship between childhood traumas and sleep quality. Conclusions: The findings highlight the clinical relevance of dissociative experiences and sleep disturbances in the heterogeneous presentation of MDD and their association with illness severity and suicidality. In the follow-up and treatment process of patients with MDD, risk and protective factors should be evaluated together, and individualized treatment programs should be targeted.
dc.identifier.doi10.3390/jcm15062364
dc.identifier.issn2077-0383
dc.identifier.issue6
dc.identifier.pmid41899289
dc.identifier.scopus2-s2.0-105033895693
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://doi.org/10.3390/jcm15062364
dc.identifier.urihttps://hdl.handle.net/20.500.12899/5190
dc.identifier.volume15
dc.identifier.wosWOS:001727022100001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMdpi
dc.relation.ispartofJournal of Clinical Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260612
dc.subjectChildhood Trauma
dc.subjectDissociation
dc.subjectMajor Depressive Disorder
dc.subjectPosttraumatic Growth
dc.subjectSuicide
dc.subjectSleep Quality
dc.titleClinical Heterogeneity of Major Depressive Disorder: The Role of Trauma, Dissociation, and Sleep
dc.typeArticle

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu