Stereological and Morphometric Analysis of MRI Chiari Malformation Type-1

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dc.authoridHaktanir, Alpay/0009-0002-5745-1075
dc.contributor.authorAlkoc, Ozan Alper
dc.contributor.authorSongur, Ahmet
dc.contributor.authorEser, Olcay
dc.contributor.authorToktas, Muhsin
dc.contributor.authorGonul, Yucel
dc.contributor.authorEsi, Ertap
dc.contributor.authorHaktanir, Alpay
dc.date.accessioned2025-10-24T18:09:46Z
dc.date.available2025-10-24T18:09:46Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractObjective : In this study, we aimed to investigate the underlying ethiological factors in chiari malformation (CM) type-I (CMI) via performing volumetric and morphometric length-angle measurements. Methods : A total of 66 individuals [33 patients (20-65 years) with CMI and 33 control subjects] were included in this study. In sagittal MR images, tonsillar herniation length and concurrent anomalies were evaluated. Supratentorial, infratentorial, and total intracranial volumes were measured using Cavalieri method. Various cranial distances and angles were used to evaluate the platybasia and posterior cranial fossa (PCF) development. Results : Tonsillar herniation length was measured 9.09 +/- 3.39 mm below foramen magnum in CM group. Tonsillar herniation/concurrent syringomyelia, concavity/defect of clivus, herniation of bulbus and fourth ventricle, basilar invagination and craniovertebral junction abnormality rates were 30.3, 27, 18, 2, 3, and 3 percent, respectively. Absence of cisterna magna was encountered in 87.9% of the patients. Total, IT and ST volumes and distance between Chamberlain line and tip of dens axis, Klaus index, clivus length, distance between internal occipital protuberance and opisthion were significantly decreased in patient group. Also in patient group, it was found that Welcher basal angle/Boogard angle increased and tentorial slope angle decreased. Conclusion : Mean cranial volume and length-angle measurement values significantly decreased and there was a congenital abnormality association in nearly 81.5 percent of the CM cases. As a result, it was concluded that CM ethiology can be attributed to multifactorial causes. Moreover, congenital defects can also give rise to this condition.
dc.identifier.doi10.3340/jkns.2015.58.5.454
dc.identifier.endpage461
dc.identifier.issn2005-3711
dc.identifier.issn1598-7876
dc.identifier.issue5
dc.identifier.pmid26713146
dc.identifier.scopus2-s2.0-84949682043
dc.identifier.scopusqualityQ2
dc.identifier.startpage454
dc.identifier.urihttps://doi.org/10.3340/jkns.2015.58.5.454
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3816
dc.identifier.volume58
dc.identifier.wosWOS:000368504400008
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherKorean Neurosurgical Soc
dc.relation.ispartofJournal Of Korean Neurosurgical Society
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_20251023
dc.subjectCavalieri method; Morphometry; Chiari malformation; MRI
dc.titleStereological and Morphometric Analysis of MRI Chiari Malformation Type-1
dc.title.alternativeStereological and morphometric analysis of mri chiari malformation type-1
dc.typeArticle

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