Relieving the pressure: the effect of active carbon dioxide aspiration on postoperative pain after laparoscopic cholecystectomy

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dc.contributor.authorGokdere, Osman Gokhan
dc.contributor.authorOndes, Bahadir
dc.contributor.authorAydin, Ahmet
dc.date.accessioned2026-06-19T06:38:17Z
dc.date.available2026-06-19T06:38:17Z
dc.date.issued2026
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground Residual carbon dioxide (CO2) after laparoscopic cholecystectomy (LC) may contribute to early postoperative pain. Active aspiration of CO2 has been proposed as a simple adjunct, but large cohort data remain limited. Methods This non-randomized prospective cohort study included 270 patients undergoing LC between May 2025 and October 2025. Patients were allocated to either the active aspiration group (n = 135) or the passive evacuation group (n = 135). Pain was evaluated using the Visual Analog Scale (VAS) at 4 and 24 h. Statistical analyses included chi-square tests, independent and paired t-tests, and Pearson correlation. A priori power analysis determined that 266 patients (133 per group) were required (effect size d = 0.40, alpha = 0.05, power = 0.90). Results The aspiration group had significantly lower pain scores at both 4 h (3.48 +/- 1.08 vs. 5.30 +/- 1.60; p < 0.001) and 24 h (1.69 +/- 0.94 vs. 3.59 +/- 1.38; p < 0.001). Active aspiration was associated with lower pain scores at both time points (p < 0.001). Conclusion Active evacuation of residual CO2 was associated with lower postoperative pain scores following LC. Given the non-randomized design, causal inference is limited, and the findings should be interpreted cautiously.
dc.identifier.doi10.1186/s12893-026-03567-y
dc.identifier.issn1471-2482
dc.identifier.issue1
dc.identifier.orcid0000-0002-8080-9664
dc.identifier.pmid41639787
dc.identifier.scopus2-s2.0-105032701155
dc.identifier.scopusqualityQ2
dc.identifier.urihttps://doi.org/10.1186/s12893-026-03567-y
dc.identifier.urihttps://hdl.handle.net/20.500.12899/5485
dc.identifier.volume26
dc.identifier.wosWOS:001712654500001
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherBmc
dc.relation.ispartofBmc Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzKA_WOS_20260612
dc.subjectLaparoscopic Cholecystectomy
dc.subjectActive Gas Aspiration
dc.subjectCarbon Dioxide Evacuation
dc.subjectPostoperative Pain
dc.subjectVisual Analog Scale
dc.titleRelieving the pressure: the effect of active carbon dioxide aspiration on postoperative pain after laparoscopic cholecystectomy
dc.typeArticle

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