A corrosive oesophageal burn model in rats: Double-lumen central venous catheter usage
Küçük Resim Yok
Tarih
2015
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Medknow Publications B9, Kanara Business Centre, off Link Road, Ghatkopar (E) Mumbai 400 075
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: We aimed to create a new and less invasive experimental corrosive oesophageal burn model using a catheter without a gastric puncture (gastrotomy). Materials and Methods: We conducted the study with two groups composed of 8 male rats. The experimental oesophageal burn was established by the application of 10% sodium hydroxide to the distal oesophagus under a pressure of 20 cmH <inf>2</inf> O, via 5-F double-lumen central venous catheter without a gastrotomy. The control group was given 0.9% sodium chloride. All rats were killed 24 h after administration of NaOH or 0.9% NaCl. Histologic damage to oesophageal tissue was scored by a single pathologist blind to groups. Results: The rats in the control group were observed to have no pathological changes. Corrosive oesophagitis (tissue congestion, oedema, inflammation, ulcer and necrosis) was observed in rats exposed to NaOH. Conclusion: We believe that an experimental corrosive oesophageal burn can safely be created under same hydrostatic pressure without a gastric puncture using this model. © 2016 Elsevier B.V., All rights reserved.
Açıklama
Anahtar Kelimeler
Corrosive burn, method, oesophagus
Kaynak
African Journal of Paediatric Surgery
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
12
Sayı
4
