A corrosive oesophageal burn model in rats: Double-lumen central venous catheter usage

Basit Öğe Kaydı
dc.contributor.authorBakan, Vedat
dc.contributor.authorÇiralik, Harun
dc.contributor.authorKartal, Seyfi
dc.date.accessioned2025-10-24T18:06:44Z
dc.date.available2025-10-24T18:06:44Z
dc.date.issued2015
dc.departmentMalatya Turgut Özal Üniversitesi
dc.description.abstractBackground: We aimed to create a new and less invasive experimental corrosive oesophageal burn model using a catheter without a gastric puncture (gastrotomy). Materials and Methods: We conducted the study with two groups composed of 8 male rats. The experimental oesophageal burn was established by the application of 10% sodium hydroxide to the distal oesophagus under a pressure of 20 cmH <inf>2</inf> O, via 5-F double-lumen central venous catheter without a gastrotomy. The control group was given 0.9% sodium chloride. All rats were killed 24 h after administration of NaOH or 0.9% NaCl. Histologic damage to oesophageal tissue was scored by a single pathologist blind to groups. Results: The rats in the control group were observed to have no pathological changes. Corrosive oesophagitis (tissue congestion, oedema, inflammation, ulcer and necrosis) was observed in rats exposed to NaOH. Conclusion: We believe that an experimental corrosive oesophageal burn can safely be created under same hydrostatic pressure without a gastric puncture using this model. © 2016 Elsevier B.V., All rights reserved.
dc.identifier.doi10.4103/0189-6725.172560
dc.identifier.endpage250
dc.identifier.issn0189-6725
dc.identifier.issn0974-5998
dc.identifier.issue4
dc.identifier.pmid26712289
dc.identifier.scopus2-s2.0-84954115002
dc.identifier.scopusqualityQ3
dc.identifier.startpage247
dc.identifier.urihttps://doi.rog/10.4103/0189-6725.172560
dc.identifier.urihttps://hdl.handle.net/20.500.12899/3184
dc.identifier.volume12
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoen
dc.publisherMedknow Publications B9, Kanara Business Centre, off Link Road, Ghatkopar (E) Mumbai 400 075
dc.relation.ispartofAfrican Journal of Paediatric Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı
dc.rightsinfo:eu-repo/semantics/openAccess
dc.snmzScopus_20251023
dc.subjectCorrosive burn
dc.subjectmethod
dc.subjectoesophagus
dc.titleA corrosive oesophageal burn model in rats: Double-lumen central venous catheter usage
dc.typeArticle

Dosyalar

Koleksiyon

Scopus İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu